{"id":989,"date":"2022-01-15T09:50:58","date_gmt":"2022-01-15T09:50:58","guid":{"rendered":"https:\/\/greek-scientists-society.com\/blog\/?p=989"},"modified":"2022-01-15T10:53:13","modified_gmt":"2022-01-15T10:53:13","slug":"mit-professor-ron-weiss-on-mammalian-synthetic-biology-foundation-and-therapeutic-applications","status":"publish","type":"post","link":"https:\/\/greek-scientists-society.com\/blog\/2022\/01\/15\/mit-professor-ron-weiss-on-mammalian-synthetic-biology-foundation-and-therapeutic-applications\/","title":{"rendered":"MIT Professor Ron Weiss on “Mammalian Synthetic Biology Foundation and Therapeutic Applications”"},"content":{"rendered":"\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t
Synthetic biology is revolutionizing how we conceptualize and approach the engineering of biological systems. Recent advances in the field are allowing us to expand beyond the construction and analysis of small gene networks towards the implementation of complex multicellular systems with a variety of applications.<\/div>
\u00a0<\/div>
In this talk, Prof. Weiss will describe our integrated computational \/ experimental approach to engineering complex behavior in a variety of cells, with a focus on mammalian cells. In his research apply appropriate design principles from electrical engineering and other established fields.<\/div>
\u00a0<\/div>
These principles include abstraction, standardization, modularity, and computer-aided design. But there is also spend considerable effort towards understanding what makes synthetic biology different from all other existing engineering disciplines and discovering new design and construction rules that are effective for this unique discipline.<\/div>
\u00a0<\/div>
Prof. Weiss will briefly describe the implementation of genetic circuits and modules with finely-tuned digital and analog behavior and the use of artificial cell-cell communication to coordinate the behavior of cell populations. The first system to be presented is a multi-input genetic circuit that can detect and destroy specific cancer cells based on the presence or absence of specific biomarkers in the cell. Prof. Weiss will also discuss preliminary experimental results for obtaining precise spatiotemporal control over stem cell differentiation for tissue engineering applications. He presents a novel approach for generating and then co-differentiating hiPSC-derived progenitors with a genetically engineered pulse of GATA-binding protein 6 (GATA6) expression. He initiated a rapid emergence of all three germ layers as a combined function of GATA6 expression levels and tissue context. Ultimately obtained a complex tissue that recapitulates early developmental processes and exhibits a liver bud-like phenotype that includes haematopoietic and stromal cells, as well as a neuronal niche. This complex organoid can be used for drug development and potentially for tissue transplantation.<\/div><\/div><\/div><\/div><\/div>
\u00a0<\/div>
\u00a0<\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t
<\/div>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Synthetic biology is revolutionizing how we conceptualize and approach the engineering of biological systems. Recent advances in the<\/p>\n","protected":false},"author":2,"featured_media":1001,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_edit_lock":["1642243994:2"],"_edit_last":["2"],"_wp_page_template":["default"],"_elementor_version":["3.5.3"],"_thumbnail_id":["1001"],"morenews-meta-content-alignment":["align-content-left"],"morenews-meta-content-mode":["single-content-mode-default"],"_elementor_page_assets":["a:2:{s:7:\"scripts\";a:1:{i:0;s:18:\"elementor-frontend\";}s:6:\"styles\";a:1:{i:0;s:12:\"widget-video\";}}"],"_elementor_css":["a:6:{s:4:\"time\";i:1787799821;s:5:\"fonts\";a:0:{}s:5:\"icons\";a:0:{}s:20:\"dynamic_elements_ids\";a:0:{}s:6:\"status\";s:4:\"file\";i:0;s:0:\"\";}"],"_elementor_element_cache":["{\"timeout\":1788140965,\"value\":{\"content\":\"\\t\\t

\\n\\t\\t\\t\\t\\t\\t
\\n\\t\\t\\t\\t\\t
\\n\\t\\t\\t
\\n\\t\\t\\t\\t[elementor-element k=\\\"478991257d7337bed38b8669b2e3d585\\\" data=\\\"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\\\"]\\t\\t\\t<\\\/div>\\n\\t\\t<\\\/div>\\n\\t\\t\\t\\t\\t<\\\/div>\\n\\t\\t<\\\/section>\\n\\t\\t\\t\\t
\\n\\t\\t\\t\\t\\t\\t
\\n\\t\\t\\t\\t\\t
\\n\\t\\t\\t
\\n\\t\\t\\t\\t\\t\\t
\\n\\t\\t\\t\\t
\\n\\t\\t\\t\\t\\t\\t\\t
\\n\\t\\t\\t
<\\\/div>\\t\\t<\\\/div>\\n\\t\\t\\t\\t\\t\\t<\\\/div>\\n\\t\\t\\t\\t<\\\/div>\\n\\t\\t\\t\\t\\t<\\\/div>\\n\\t\\t<\\\/div>\\n\\t\\t\\t\\t\\t<\\\/div>\\n\\t\\t<\\\/section>\\n\\t\\t\",\"scripts\":[],\"styles\":[]}}"]},"categories":[12],"tags":[10,35],"class_list":["post-989","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-podcasts","tag-greekscientistssociety","tag-webinars"],"featured_image_urls":{"full":["https:\/\/greek-scientists-society.com\/blog\/wp-content\/uploads\/2022\/01\/RosWeiss.jpg",1462,720,false],"thumbnail":["https:\/\/greek-scientists-society.com\/blog\/wp-content\/uploads\/2022\/01\/RosWeiss-150x150.jpg",150,150,true],"medium":["https:\/\/greek-scientists-society.com\/blog\/wp-content\/uploads\/2022\/01\/RosWeiss-300x148.jpg",300,148,true],"medium_large":["https:\/\/greek-scientists-society.com\/blog\/wp-content\/uploads\/2022\/01\/RosWeiss-768x378.jpg",640,315,true],"large":["https:\/\/greek-scientists-society.com\/blog\/wp-content\/uploads\/2022\/01\/RosWeiss-1024x504.jpg",640,315,true],"1536x1536":["https:\/\/greek-scientists-society.com\/blog\/wp-content\/uploads\/2022\/01\/RosWeiss.jpg",1462,720,false],"2048x2048":["https:\/\/greek-scientists-society.com\/blog\/wp-content\/uploads\/2022\/01\/RosWeiss.jpg",1462,720,false],"morenews-featured":["https:\/\/greek-scientists-society.com\/blog\/wp-content\/uploads\/2022\/01\/RosWeiss-1024x504.jpg",1024,504,true],"morenews-large":["https:\/\/greek-scientists-society.com\/blog\/wp-content\/uploads\/2022\/01\/RosWeiss-825x575.jpg",825,575,true],"morenews-medium":["https:\/\/greek-scientists-society.com\/blog\/wp-content\/uploads\/2022\/01\/RosWeiss-590x410.jpg",590,410,true]},"author_info":{"display_name":"Theo Zacharis","author_link":"https:\/\/greek-scientists-society.com\/blog\/author\/theo-zacharis\/"},"category_info":"Webinars&Podcasts<\/a>","tag_info":"Webinars&Podcasts","comment_count":"471","_links":{"self":[{"href":"https:\/\/greek-scientists-society.com\/blog\/wp-json\/wp\/v2\/posts\/989","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/greek-scientists-society.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/greek-scientists-society.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/greek-scientists-society.com\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/greek-scientists-society.com\/blog\/wp-json\/wp\/v2\/comments?post=989"}],"version-history":[{"count":5,"href":"https:\/\/greek-scientists-society.com\/blog\/wp-json\/wp\/v2\/posts\/989\/revisions"}],"predecessor-version":[{"id":1002,"href":"https:\/\/greek-scientists-society.com\/blog\/wp-json\/wp\/v2\/posts\/989\/revisions\/1002"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/greek-scientists-society.com\/blog\/wp-json\/wp\/v2\/media\/1001"}],"wp:attachment":[{"href":"https:\/\/greek-scientists-society.com\/blog\/wp-json\/wp\/v2\/media?parent=989"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/greek-scientists-society.com\/blog\/wp-json\/wp\/v2\/categories?post=989"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/greek-scientists-society.com\/blog\/wp-json\/wp\/v2\/tags?post=989"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}